Product Name: Vinca Rosea Extract
Latin Name: Catharanthus Roseus (L. )G.Don / Vinca Minor L.
Specification:
Catharanthine >95%,
Vinpocetine > 98%
4:1~20:1.
Appearance: White or Slightly Yellow,Crystalline Powder
Other name: Catharanthin, (+)-3,4-Didehydrocoronaridine,Vinpocetine
Molecular formula: C21H24N2O2
Molecular weight: 336.42746
Part of the Plant Used: Flower (Dried, 100% Natural)
Extract Method: Grain Alcohol/Water
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Basic Information of Vinpocetine:
CAS No.: 42971-09-5
Molecular Formula: C22H26N2O2
Molecular Weight: 350.5
Synonyms: Ethyl-apovincaminate; 3a,16a-Apovincaminic acid ethyl ester; (3a,16a)-Eburnamenine-14-carboxylic acid ethyl ester;Ethyl apovincamin-22-oate; RGH-4405
Solubility: Soluble in acetic acid, DMSO (5 mg/ml), acetone (25 mg/ml), chloroform, and slightly soluble in ethanol (10 mg/ml) and other alcohols. Insoluble in water. Store solutions aliquoted at -20°C for up to 3 months.
Appearance: Fine white power
What is Vinca Rosea Extract?
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).
Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.
Microtubule disruptive drugs like vinblastine, colcemid, nocodazole have been reported to act by two mechanisms. At very low concentrations they suppress microtubule dynamics and at higher concentrations they reduce microtubule polymer mass. Recent findings indicate that they also produce microtubule fragments by stimulating microtubule minus-end detachment from their organizing centers. Dose-response studies further indicate that enhanced microtubule detachment from spindle poles correlate best with cytotoxicity.
Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. It is also used to treat histiocytosis according to the established protocols of the Histiocytosis Association of America.
Where will be Vinca Rosea Extract used for?
Because some people think vinpocetine might improve blood flow to the brain, it is used for enhancing memory and preventing Alzheimer’s disease and other conditions that harm learning, memory, and information processing skills as people age.
Vinpocetine is also used for preventing and reducing the chance of disability and death from ischemic stroke. This is the type of stroke that occurs when a blood clotstops blood flow in the brain, causing brain cells (neurons) to die because they are not receiving oxygen. People try vinpocetine for preventing and treating stroke right after it happens because they think vinpocetine might help keep blood from clotting and might also protect neurons against the harmful effects of oxygen deprivation.
Other uses for vinpocetine include treating symptoms of menopause, chronic fatiguesyndrome (CFS), and seizure disorders; and preventing motion sickness.
Action :
1. It has vasodilating, blood thinning, and memory-enhancing actions.
2. It acts as a cerebral stimulant and vasodilator.
3. It is used to treat arteriosclerosis.
4. It is very effective in curing dementia caused due to insufficient blood supply to the brain.
5. It interferes with cells' ability to synthesize DNA and RNA.
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Pharma Sources Insight June 2024: Globalization on the Go
