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Zhejiang Retron Biotech Co., Ltd.
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Copovidone is a white powder or transparent, translucent solution, odorless or slightly characteristic odor, soluble in water, ethanol and other organic solvents, with good adhesion, hygroscopicity, film-forming and surface activity. It can be used as a binder in wet tablet processing, dry granulation and powder direct pressing processes to improve particle compressibility, as a coating film former for tablet film coating, as a pore-forming agent for flavor masking and extended-release formulations, and as a solubilizer in solid dispersion processes. |
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Shanghai Yearn Chemical Science-Tech Co.,Ltd
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Product Name: Copovidone (VA64)
USP/EP name Copovidone,
INCI: PVP/VA copolymer 60/40
CAS NO. 25086-89-9
Appearance properties White to light yellow free flowing powder, good fluidity, tasteless or slightly characteristic odor;
Powder moisture absorption is less than K30, soluble in water, ethanol and other organic solvents, lower than K30 glass transition temperature, can form a transparent water soluble film;
Product standards meet USP3/NF, EP, BP, JPE
[Product use]: Used as gas chromatography fixing liquid
[Product packaging]: self-sealing bag; Aluminum foil bag; A cardboard box; Cardboard drum (or packed according to customer requirements)
[Storage conditions]: cool, dry, avoid light, avoid high temperature
[Validity]:24 months
Copovidone is a linear copolymer of N-vinylpyrrolidone (NVP) and vinyl acetate (VA), which is a water-soluble polymer resin. It is a white powder, odorless, tasteless, easy to absorb moisture, soluble in water, ethanol and anhydrous alcohols, and has good adhesion, hygroscopicity, film formation and surface activity.
Since copovidone is a copolymerization structure of NVP and VA, it has the properties of both PVP and PVAC. Compared with the properties of the above three products, copovidone retains the good water solubility, cohesiveness and film forming properties of PVP, and has relatively lower water absorption and broader solubility, better plasticity and stronger surface activity than PVP (note: affinity for hydrophobic surface is greater than PVP). Therefore, this product is an excellent tablet adhesive, and the tablets produced by it have the characteristics of high hardness and low brittleness, and can be less bonded under wet conditions, especially for the preparation and granulation of high dose, poor water solubility and water-sensitive drugs.
At the same time, this product is also an excellent film forming agent, used in tablets, particles, pellets and sugar-coated chip core coating solution and local drug spray. The film coating and spray film prepared with this product have good flexibility, low water absorption, high plasticity and low viscosity.
As a binder for tablets and granules, it can be completed by wet method, dry method or direct tablet method, and in most cases its dosage is 2-5% of the total preparation, generally about 3%, and the concentration of the adhesive is generally 5-10%. According to different substances and excipients, water or hexanol, isopropyl alcohol, etc., can be used as solvents respectively. When the direct tablet method is used, the amount is generally about 5%, can use lactose, sorbide, mannitol, microcrystalline cellulose and other excipient, but pay attention to control the moisture content of the ingredients to maintain proper adhesion.
As a film coating, it is often used in combination with cellulose derivatives, shellac and high molecular weight polyethylene glycol to improve the strength of the film and adjust the flexibility and solubility of the film. Under normal circumstances, it is not necessary to add ester plasticizers.
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