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Sinoway Industrial Co.Ltd.
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Product name
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2,4-Dichloropyrimidine；
2,6-Dichloropyrimidine;
Pyrimidine, 2,4-dichloro-;
Osimertinib intermediate
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CAS No.
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3934-20-1
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Molecular Formula
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C4H2Cl2N2
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Molecular Weight
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148.979
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Molecular Structure
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Quality Standard
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98% up by HPLC
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Appearance
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Pale yellow or off-white powder
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ANALYSIS
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SPECIFICATION
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RESULTS
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Melting point
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58-60℃
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58.5-60℃
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Appearance
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Pale yellow or off-white powder
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Conforms
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Water
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≤ 0.2%
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0.08%
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Residue on ignition
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≤ 0.3%
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0.23%
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Assay (by HPLC)
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≥ 98.0%
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99.2%
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Conclusion
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The product meets enterprise standard
CDMO service: We can customized manufacturing according to your requirement.
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What is 2,4-Dichloropyrimidine?
2,4-Dichloropyrimidine is one of key intermediates of Osimertinib. Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer (NSCLC), if the cancer cells are positive for the T790M mutation in the gene coding for EGFR or for activating EGFR mutations.
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Send Inquiry
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Haohong(Qihe) Pharmaceutical Technology Co.,ltd
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| Product Name: | 2,4-Dichloropyrimidine | | Synonyms: | 2,4-DICHLOROPYRIMIDINE;2,6-DICHLOROPYRIMIDINE;2-4-DICHLOROPYRIMIDINE CRYSTALLINE;AKOS 91058;2,4-dichloro-pyrimidin;2,4-Dichlorpyrimidin;Pyrimidine,2,4-dichloro-;2,4-Dichloropyrimidine Pazopanib | | CAS: | 3934-20-1 | | MF: | C4H2Cl2N2 | | MW: | 148.98 | | EINECS: | 223-508-6 | | Product Categories: | Building Blocks;Halogenated Heterocycles;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;Pyrimidine Series;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyrazines, Pyrimidines & Pyridazines;Aromatics Compounds;Pyrimidines;Aromatics;Heterocycles;PYRIMIDINE;Pyrazines, Pyrimidines & Pyridazines;Heterocycle-Pyrimidine series;bc0001 | | Mol File: | 3934-20-1.mol |  |
| | | 2,4-Dichloropyrimidine Chemical Properties |
| Melting point | 57-61 °C (lit.) | | Boiling point | 101 °C/23 mmHg (lit.) | | density | 1.6445 (rough estimate) | | refractive index | 1.6300 (estimate) | | Fp | 101°C/23mm | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Powder, Crystals and/or Chunks | | pka | -2.84±0.20(Predicted) | | color | White to yellow to beige or grayish | | Water Solubility | Soluble in water (partly), methanol, chloroform, and ethyl acetate. | | Sensitive | Moisture Sensitive |
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Pharma Sources Insight January 2025
