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Sinoway Industrial Co.Ltd.
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Product name
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Diosmin
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CAS No.
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520-27-4
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Molecular Formula
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C28H32O15
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Molecular Weight
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608.54
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Quality Standard
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99% up, Medicine Grade
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Appearance
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Light yellow fine powder
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Function of Diosmin
Diosmin is also called Alvenor. It is a kind of drug for the treatment of hemorrhoid symptoms related to acute episodes, can also be used in the treatment of symptoms associated with venous lymphatic insufficiency (leg heavy, pain, morning acid swells discomfort).
The effects of diosmin are as below:
1, Has specific affinity to the venous system, enhance the tension system without affecting the artery of vein;
2, To the microcirculation system, decrease the blood viscosity, improve the velocity of reducing silt up;
3, Contract the lymphatic system, which can enhance lymphatic and lymph drainage speed, speed up the return relieve edema.
4, Commercially available diosmin uses micronization technology, increase the contact area after using medicine, absorb more and higher bioavailability. Suitable for all kinds of hemorrhoids and acute hemorrhoids, also can be used for the treatment of chronic venous insufficiency, such as varicose veins, leg ulcers, etc.
Diosmin is widely used in food, medicine, health products, etc
Action mechanism of diosmin:
1.Enhance the vein tension, even not exceptional under high temperature condition. It has a stronger effect causing the constriction of vein than other drugs such as rutin, still can enhance the tension of the vein when the body was acidosis. Diosmin has specific affinity for vein without affecting the arterial system.
2. Improve microcirculation. Diosmin can obviously reduce the white blood cells and vascular endothelial cell adhesion, migration, disintegrating the release of inflammatory substances, such as histamine, slow excitation peptide, complement, leukotriene, prostaglandins, and too many free radicals, reducing the permeability of capillaries and enhance its tension. Diosmin can lower blood viscosity, enhance the function of red blood cell velocity, thus reduce the microcirculation clogged.
3. Promote lymphatic circumfluence. Diosmin can increase the speed of lymphatic drainage. |
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PINGYU YIMEIKANG PLANT TECHNOLOGY CO.,LTD
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| Name: Diosmin |
| CAS#: 520-27-4 |
| Botanical Source: Immature bitter orange |
| Specification: EP, HPLC 90%--98%, Micronized Powder or Granule |
| Function & Application: Diosmin is a drug used to treat various symptoms related to the acute attack of hemorrhoids. It can also be used to treat various symptoms related to venous lymphatic insufficiency (feelling of heaviness of the legs, pain, soreness and discomfort in the morning). |
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| TEST ITEM |
STANDARD |
RESULT |
| Appearance |
Greyish-yellow or light yellow hygroscopic powder |
Complies (Visual) |
| Melting point |
277℃-278℃ |
Complies(Melting point apparatus) |
| Identification |
(a)(b) Must Positive |
Complies |
| Solubility |
|
|
| - in water |
Insoluble |
Complies |
| - in dimethyl sulfoxide |
Soluble |
Complies |
| - alcohol |
Insoluble |
|
| - dilute solutions of alkali hydroxides |
Soluble |
|
| Residue on ignition |
≤0.5% |
Complies |
| Mesh size |
100% pass 80 mesh/2000 mesh |
Complies |
| Iodine |
≤0.1% |
Complies (Potentiostat) |
| Related substances |
|
|
| - acetoisovanillone |
≤0.5% |
Complies (HPLC) |
| - hesperidin |
≤4.0% |
Complies (HPLC) |
| - isorhoifolin |
≤3.0% |
Complies (HPLC) |
| - 6-iododiosmin |
≤0.6% |
Complies (HPLC) |
| - linarin |
≤3.0% |
Complies (HPLC) |
| - diosmetin |
≤2.0% |
Complies (HPLC) |
| - unspecified impurities |
≤0.4% |
Complies (HPLC) |
| - total |
≤8.5% |
Complies (HPLC) |
| Heavy metals |
90%---102% |
Complies (HPLC) |
| Water |
≤6.0% |
Complies (K.F) |
| Residual solvents |
|
|
| - methanol |
≤3000ppm |
Complies (HPGC) |
| - acetic acid |
≤5000ppm |
Complies (HPGC) |
| - pyridine |
≤200ppm |
Complies (HPGC) |
| Assay |
|
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| MICROBIOLOGICAL TEST |
STANDARD |
RESULT |
| Total microbial count |
≤1000cfu/g |
Complies |
| Yeast & mold |
≤100cfu/g |
Complies |
| E.Coli |
Negative |
Negative |
| Salmonella |
Negative |
Negative |
| |
| Packaging: The usual packaging is 25kg net carton drum or box with a polyethylene bag in side. |
| Storage: Preserve in well closed,light resistant and dry environment. |
|
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