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Benepure Pharmaceutical Co., Ltd.
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Product Name: BaicaleinBaicalein
Synonym: Scutellaria Baicalensis Extract
CAS Number: 491-67-8
Specification: 98%HPLC
Appearance: Light yellow fine powder
Botanical Source: Scutellaria baicalensis Georgi
Baicalin is a perennial herb of the genus Baicalin. The root of Baicalin is used as medicine.
Baicalin Root Extract Baicalin isolated compounds called flavonoids. It has significant biological activity, has antibacterial, diuretic, anti-inflammatory, anti-metamorphosis and antispasmodic effect, and has strong anti-cancer response to physiological performance . Has played an important role in clinical medicine.
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Sinoway Industrial Co.Ltd.
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| Name |
Baicalein
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EINECS |
N/A |
| CAS No. |
491-67-8 |
Density |
1.548 g/cm3 |
| PSA |
90.90000 |
LogP |
2.57680 |
| Solubility |
N/A |
Melting Point |
256-271 °C(lit.) |
| Formula |
C15H10O5 |
Boiling Point |
575.932 °C at 760 mmHg |
| Molecular Weight |
270.241 |
Flash Point |
225.257 °C |
| Transport Information |
N/A |
Appearance |
Yellow crystalline solid |
| Safety |
26-36 |
Risk Codes |
36/37/38-20/21/22 |
| Molecular Structure |
 |
Hazard Symbols |
 Xi, Xn |
| Synonyms |
Baicalein(6CI);Flavone, 5,6,7-trihydroxy- (7CI,8CI);5,6,7-Trihydroxyflavone;NSC 661431;Noroxylin;
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Han Traceability(Shaanxi) Biological Technology Co.,Ltd
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Baicalein is a phenolic flavonoid presented in the dry roots of Scutellaria baicalensis Georgi. It has been reported that baicalein possesses a number of biological properties, such as antiviral, antioxidative, anti-inflammatory, antithrombotic, and anticancer properties. However, the effect of baicalein on mastitis has not yet been reported. This research aims to detect the effect of baicalein on lipopolysaccharide (LPS)-induced mastitis in mice and to investigate the molecular mechanisms. Baicalein was administered intraperitoneally 1 h before and 12 h after LPS treatment. The results indicated that baicalein treatment markedly attenuated the damage of the mammary gland induced by LPS, suppressed the activity of myeloperoxidase (MPO) and the levels of tumor necrosis factor (TNF-α) and interleukin (IL-1β) in mice with LPS-induced mastitis. Besides, baicalein blocked the expression of Toll-like receptor 4 (TLR4) and then suppressed the phosphorylation of nuclear transcription factor-kappaB (NF-κB) p65 and degradation inhibitor of NF-κBα (IκBα) and, and inhibited the phosphorylation of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK) in mitogen-activated protein kinase (MAPK) signal pathway. These findings suggested that baicalein may have a potential prospect against mastitis.
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