Levodopa (Levodopa) is a precursor drug of dopamine (DA). It has no pharmacological activity and enters the central nervous system through the blood-brain barrier. It plays a pharmacological role by converting dopamine decarboxylase into DA.
The improvement of myotonia and bradykinesia is obvious. Continuous medication is also effective for tremor, salivation, postural instability and dysphagia.
1. Parkinson's disease (paralysis tremors)
Symptomatic Parkinson's syndrome (non-drug induced paralysis tremor syndrome) after encephalitis or with cerebral arteriosclerosis and carbon monoxide and manganese poisoning of the central nervous system. Can reduce the symptoms of paralysis tremors, improve muscle tension, make limb movement more normal. The effect is good for mild and moderate patients, but worse for severe or elderly patients.
2. Hepatic encephalopathy
Can make the patient awake, improve symptoms. Hepatic encephalopathy may be related to abnormal dopamine, the central transmitter. It is also thought that levodopa can improve the tolerance of the brain to ammonia, but can not improve liver injury and liver function.
3. The neuralgia
Early administration can relieve neuralgia.
4. Hyperprolactinemia
It can inhibit hypothalamic thyrotropin releasing hormone and excitatory prolactin releasing inhibiting factor, thus reducing the secretion of prolactin. It is used to treat hyperprolactinemia and has certain curative effect on galactophia.
5. Alopecia
The mechanism may be to increase the concentration of catecholamines in the blood to the tissues, promoting hair growth.
6. Promote the growth and development of children
It can accelerate the growth and development of children's bones by promoting the secretion of growth hormone. Treatment of children with hypophysis.
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Pharma Sources Insight June 2024: Globalization on the Go
