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Sinoway Industrial Co.Ltd.
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Product name
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Prednisolone
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CAS No.
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50-24-8
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Molecular Formula
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C21H28O5
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Molecular Weight
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360.444
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Quality Standard
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97% up by HPLC, EP8/USP38/BP2014
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Appearance
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White powder
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Items
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Specifications
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Results
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Appearance
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White or almost white crystalline powder
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White crystalline powder
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Identification
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A;B
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Meets test
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Specific rotation
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+97°~+103°
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+99°
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Chromatogram purity
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Any peak≤1.0%
Only one peak＞0.50%
Total≤2.0%
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Epi-prednisolone＜0.05%
Hydrocortisone: 0.79%
11-Deoxypredmosolone＜0.05%
Other detected imputiry: RRT (0.81) 0.06%
Total: 0.85%
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Loss on drying
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≤0.5%
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0.1%
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Residue on ignition
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Negligible
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Negligible
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Selenium
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≤0.003%
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＜0.003%
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Residual solvents
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Methanol≤700ppm
Methylene chloride≤600ppm
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29ppm
507ppm
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Assay
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97.0~102.0%
(on dried substance)
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99.0%
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Conclusion
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It conforms to USP38
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Micronized
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≤15μm＞80%;≤30μm＞98%
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Function of Prednisolone
Prednisolone is an adrenal cortex hormone drug. Super-physiological glucocorticoids have a variety of pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression.
1. Anti-inflammatory effects: glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the performance of inflammation.
2. Immunosuppressive effects: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, reduce the number of T lymphocytes and monocyte eosinophils, reduce the binding ability of immunoglobulins and cell surface receptors, and inhibit interleukins Synthesis and release, thereby reducing the transformation of T cells to lymphoblasts, and reducing the expansion of the primary immune response.
3. Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a role in protecting the body. |
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