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Amicogen (China) Biopharm Co., Ltd
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Tulathromycin is a novel triamilide antimicrobial that has been approved for use in the treatment and prevention of bovine respiratory disease and the treatment of swine respiratory disease in the European Union and the United States. The agent penetrates gram-negative bacteria well, and it exhibits mixed bacteriostatic and bactericidal activity. Tulathromycin is formulated as a ready-to-use, sterile aqueous solution, and the packaged concentration of 100 mg tulathromycin/ml allows low-volume dosing. This agent is characterized by rapid absorption from the injection site, extensive distribution to tissue, and slow elimination, thereby providing high, prolonged drug concentration in the lungs. Studies show that a single dose of tulathromycin is effective in treating cattle and swine with respiratory disease and in preventing high-risk cattle from developing respiratory disease. |
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HANGZHOU WENLEE CHEMICAL CO LTD
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【Product】 Tulathromycin A
【CAS NO】 217500-96-4
【Molecular Formula】 C41H79N3O12
【Molecular weight】 806.084
【Character】
【Purity】
【Structural formula】
【Main Function】 Used as an organic synthesis intermediate and solvent
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Sinoway Industrial Co.Ltd.
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Product name
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TULATHROMYCIN
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CAS No.
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217500-96-4
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Molecular Formula
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C41H79N3O12
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Molecular Weight
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806
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Quality Standard
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95% up, Vet-GMP
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Appearance
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White Powder
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TEST
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SPECIFICATION
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RESULTS
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Appearance
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White or off white powder
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White powder
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Solubility
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Not soluble in water,soluble in ethanol
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Conform
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Assay(HPLC)
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95.0%-103.0%
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98.9%
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Optical rotation
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Between -22°and -26°at 589 nm and 25°C, from the 40mg/ml concentration of acetonitrile solution
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-23.3°
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Identification
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The retention time of major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay
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Conform
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Residual solvents
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Contain not more than 600ppm of methylene chloride(CH2Cl2)
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Conform
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Contain not more that 5000ppm of n-heptane(C7H16)
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Conform
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Moisture
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Not more than 0.50%
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0.40%
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Heavy Metals
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Not more than 20ppm
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Conform
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Related substances
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Individually: Not more than 3.0%
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1.0%
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Total: Not more than 6.0%
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2.9%
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Residue on ignition
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Not more than 0.20%
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0.04%
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CONCLUSION
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Complies with EP standards
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Function of Tulathromycin
Tulathromycin is a newly marketed and animal-specific semi-synthetic macrolide antibiotic. It is mainly used for the respiration of pigs and cattle caused by Actinobacteria, Mycoplasma, Pasteurella, and Haemophilus parahaemophilus. System diseases. It has many advantages, such as low dosage, one-time administration, low residue and animal specific use. In my country, the most widely used macrolide drugs are tylosin and tilmicosin. Although these two drugs have achieved good results in production, with the prolonged use of time, many in my country Different levels of drug resistance have appeared in the region, leading to increasing dosages, but the therapeutic effect is gradually decreasing, and the efficacy of tyramycin is stronger than that of tylosin and tilmicosin, which are widely used in the market. Therefore, the use of tulathromycin in livestock and poultry production is very promising. |
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Pharma Sources Insight January 2025
