Factory Supply 99% Synthetic Liraglutide Powder Peptide API CAS NO 204656-20-2
Introduction:
Liraglutide is a long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis.
Liraglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to liraglutide therapy.
Liraglutide is a lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a glucagon-like peptide-1 receptor agonist and a neuroprotective agent. It is a lipopeptide and a polypeptide.
Fuction &Application:
Liraglutide has the following pharmacological effects:
Protective effect on islet β cells
The effect of reducing body mass
Cardiovascular effects of liraglutide
Protective effect on the liver
Therapeutic effect on Alzheimer's disease (AD)
As a novel long-acting glP-1 analogue, liraglutide has 97% sequence homology with human GLP-1, which can bind and activate the GLP-1 receptor. Glp-1 receptor is the target of natural GLP-1, an endogenous intestinal Chemicalbook insulin stimulating hormone, which promotes the proliferation and differentiation of islet β cells, and significantly protects and improves the function of islet β cells. At the same time, liraglutide is simple and convenient to use, can provide 24h blood glucose control once a day, and the risk of hypoglycemia is small, and is expected to become a new drug for the treatment of type 2 diabetes.
Certificate of Analysis
|
Product Name
|
Liraglutide |
Batch No.
|
210201
|
|
Mfg. Date
|
Feb 22, 2021
|
Exp. Date
|
Feb 21, 2023
|
|
Sequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(palm-gama-Glu)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
molecular formula：C172H265N43O51， molecular weight：3751.202
|
|
|
|
Test
|
Specification
|
Results
|
|
Appearance
|
White powder
|
Conforms
|
|
Solubility
|
Soluble in water
|
Conforms
|
|
Purity (HPLC)
|
NLT 98.0%
|
99.5%
|
|
Acetic Acid
|
NMT 8%
|
0.4%
|
|
Mass spectrum
|
3751.3±1.0 |
3751.8 |
|
Peptide content (N%)
|
NLT80%
|
94.8%
|
|
Wate Content (Karl Fischer）
|
NMT7.0%
|
3.8%
|
Storage:In an air tight container,protected from light at temperature2-8℃. Conclusion:the product complies with enterprise standard.
Not for human use without further processing.
Why Choose Us:
1.Stable quality, high quality satisfy customer's high grade sourcing request.
2.Competitive price .
3.Correct delivery time promise.
4.Continuous improvement make sure the long-term cooperation.
5.Honest service for your whole sourcing process.
Ench Industry is the professional Oxytocin CAS 50-56-6
Welcome your inquiry and cooperation ,feel free to contact with us !
Contact us:
Call us by 008613675847137
Email us at jayjie@hjy.com
Contact by QQ 1430571263
|
Pharma Sources Insight June 2024: Globalization on the Go
