|
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
|
The Inclusion Of Hydroxypropyl-beta-cyclodextrin In Weak Polar Organic Pollutants In Soil - HPBCD - News - Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
As a new solubilizing agent, cyclodextrin and its derivatives can form inclusions with weakly polar organic pollutants, thereby significantly increasing their solubility in water. For example, by studying the removal and migration of weakly polar contaminants from soil by hydroxypropyl-beta-cyclodextrin, the results show that hydroxypropyl-beta-cyclodextrin does not adsorb on the soil, and its existence can be Weakly polar contaminants (such as trichloroethylene, naphthalene, biphenyl, 2-chlorobiphenyl, trichlorobenzene, hydrazine and hydrazine) have significant promotion in the removal of two soils with organic matter content of 0.29% and 12.6%, respectively. The effect, and as the concentration of HP-β-CD in the aqueous solution increases, the promotion is also enhanced.
In the absence of HP-β-CD, about 1800 times the pore volume of water in order to remove 99% of the hydrazine adsorbed in Borden soil (organic matter content of 0.29%), while using 10g / L HP-β- When the CD solution is used, only one thread volume is required to achieve the same effect. The promotion of HP-β-CD on the transport of weakly polar organics in two pore media is directly proportional to the hydrophobicity of the organic matter. For example, the presence of HP-β-CD reduced the retention factor for hydrazine from 161.8 to 2.4, while for trichlorobiphenyl, the retention factor decreased from 828 to 1.6.
The comparison of the promotion of HP-β-CD on the transport of organic pollutants in soil with the effects of other organic substances shows that HP-β-CD is stronger than other organic substances. The most obvious advantage of HP-β-CD is that it has no obvious retention or adsorption in the soil and no secondary pollution.
|
Send Inquiry
|
|
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
|
Propyl betaclodextrin is an ether derivative of betaclodextrin.The introduction of hydroxypropyl group opened the hydrogen bonds within the betacyclodextrin molecule, forming an amorphous mixture, greatly improving the water solubility, proving high safety, and even being used for intravenous injection.Therefore, it is considered as a potential substitute for maternal cyclodextrin.Betacyclodextrin reacts with epoxypropane under alkaline conditions. Under the catalysis of base, betacyclodextrin alkoxy anions attack the carbon atoms with the least substituents on the oxygen ring, where the steric hindrance is the least.Cyclodextrin and epoxypropane react easily to form 6 substituents in strong alkaline environment, and 2 substituents in weak alkaline condition.The hydroxyl groups at the 2, 3 and 6 sites are activated under strong alkaline conditions, and the steric resistance at the 6 sites is the least, and the substituents are easy to enter.Under the condition of weak alkalinity, the hydroxyl group in the 2 position is the most acidic and easy to be activated, so the 2 position is the main substitute.Cyclodextrins and their derivatives have long been thought to have rigid structures, an assumption that does not accord with their ability to form complex structures easily.The structure of cyclodextrins is relatively flexible. Experiments show that cyclodextrins are flexible not only in solution, but also in solid state through non-covalent bonding.The introduction of hydroxypropyl group opened the internal hydrogen bond of betacyclodextrin, making the framework flexible and the substituents have some room to move.This relatively flexible structure can better explain the improvement of its complex formation ability and its complex reaction kinetics.At present, shandong binzhou zhiyuan biotechnology co., ltd. is the largest manufacturer of cyclodextrin derivatives in China. The product quality is first-class in China and the product types are the most in the same industry.
|
Send Inquiry
|
|
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
|
Pharmaceutical Intermediate: Hydroxypropyl-beta-cyclodextrin - HPBCD - News - Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
Hydroxypropyl-beta-cyclodextrin is an ether derivative of beta-cyclodextrin. The introduction of hydroxypropyl groups opens the hydrogen bonds in the beta-cyclodextrin molecule, forming an amorphous mixture, which greatly improves the water solubility. It has been proved to be highly safe and can even be used for intravenous injection. Hydroxypropyl-beta-cyclodextrin is therefore considered to be a potential alternative to the parent cyclodextrin. The cyclodextrin is condensed with propylene oxide under alkaline conditions. Under the base catalysis, the cyclodextrin alkoxy anion attacks the carbon atom with the least substituent on the oxygen ring, and the steric hindrance is the smallest. Cyclodextrin and propylene oxide react easily in a strong alkaline environment to form a 6-substituent, and under weak alkaline conditions, a 2-substituent is easily formed. The hydroxyl groups at positions 2, 3, and 6 are activated under strong alkaline conditions, and the steric hindrance at the 6 position is the smallest, and the substituent is easily accessible. Under the weak alkaline condition, the hydroxyl group at the 2 position is the strongest and easy to activate, so the substitution is mainly in the 2 position. It has long been believed that the structure of cyclodextrin and its derivatives is rigid, a hypothesis that does not conform to the nature of the complexes they can easily form. Its structure is relatively flexible, and experiments have shown that cyclodextrin forms a complex by non-covalent bonding not only in solution, but also in a solid state. The introduction of hydroxypropyl opens the internal hydrogen bond of beta-cyclodextrin, making the backbone flexible and the substituents also have some activity space. This relatively flexible structure can better explain the improvement of the composite forming ability and the composite reaction kinetics.
|
Send Inquiry
|
Pharma Sources Insight June 2024: Globalization on the Go
