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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Manufacturer Of Sulfobutyl Ether-beta-cyclodextrin Sodium Salt Manufacturers, Suppliers, Factory and Company - Zhiyuan Biological Name: sulfobutyl ether-beta-cyclodextrin sodium salt DMF NO.: 030167 Other name : betadex sulfobutyl ether sodium ; sulfobutyl ether-β-cyclodextrin sodium salt CAS: 182410-00-0 Abbreviation: SBEBCD Molecular formula : C42H70-nO35 (C4H8O3S Na)n Molecular weight: 1135+158n Qaulity ： injection grade / oral grade Standard : USP Package: 500g/bag , 1kg/bag , 2kg/bag, 10kg/drum , 20kg/drum Use : medical Features and applications: SBE-β-CD is a high water-soluble anionic cyclodextrin derivative. It can easily form non-covalent inclusion complexes with drug molecules, thus it has the good performances in enhancing drug stability, solubility and safety, reducing drug toxicity and hemolysis, covering up bad smell, and controlling drug release rate.
SBE-β-CD has been used in injection, oral, nasal and eye medication. Modification by charged functional units can improve the binding affinity of cyclodextrins for oppositely charged guests, so it has a special affinity for drugs with nitrogen elements. |
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Sertraline is selective serotonin recycle inhibitor (SSRI), the latest in a can help to improve the ability of the body, effectively alleviate the patient's depressive symptoms, including irritable mood, and can reduce the fatigue and anxiety state of sustainability, has a long-term, low poisonous to the cells of liver, the body clear, very suitable for the elderly taking etc., in the world has been widely used to treat depressive and obsessive-compulsive disorder.Compared with sertraline hydrochloride tablets, the oral liquid containing sertraline hydrochloride has the advantages of convenient taking, stable storage at low or normal temperature, fast absorption, good taste, more suitable for elderly patients, simple process and material saving.The present invention solves the sertraline hydrochloride oral liquid preparation technology on the key problem of solubility and stability problems, choose in the use of doses non-toxic excitant hydroxypropyl times he almost cyclodextrins and sugar mixture of lauric acid ester as solubilizer and stabilizer, which provides a with hydroxypropyl times he cyclodextrins and sugar mixture of lauric acid ester as solubilizer and stabilizer of sertraline hydrochloride oral solution. Shandong binzhou wisdom source biological technology co., LTD., is committed to specializing in the production of pharmaceutical excipients hydroxypropyl times he cyclodextrins and sodium sulfonated butyl times he cyclodextrin, has standard GMP management, advanced production equipment, professional team of experts, the sale of our products at the same time, also widely used in food, cosmetics, scientific research and other fields, you just need to, we just professional, welcome from all walks of life to come to visit. |
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Oxaliplatin is the first Cyclohexanediamine platinum anticancer drug to enter the market. It has the characteristics of clear anticancer effect, low toxicity, and obvious inhibition on colorectal cancer cell lines and cisplatin resistant cell lines. The combination of oxaliplatin with 5-fluorouracil and folic acid has been used as the first-line drug in the treatment of colorectal cancer, and widely used in the treatment of gastric cancer, ovarian cancer and so on. However, oxaliplatin is slightly soluble in water and has poor stability in water. It can react with water molecules to form diamine cyclohexaneplatinum dihydrate, and its aqueous solution will gradually oxidize to dihydroxyoxaliplatin in the presence of oxygen.
It is found that when hydroxypropyl betacyl dextrin is selected as the stabilizer of oxaliplatin aqueous solution, the total amount of related substances measured according to the detection method of oxaliplatin for injection in USP can not increase more than 0.25% within 24 hours after the preparation of the solution. Compared with the current oxaliplatin aqueous solution prepared according to the existing technology, it has the advantages of providing its stability. It has obvious advantages, while hydroxypropyl beta cyclodextrin, as a skeleton agent, can be used in the lyophilized preparation of oxaliplatin. The quality of the finished product, especially the related substances, is better than the products on the market.
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a scientific and technological company focusing on the application, development and innovation of cyclodextrin and cyclodextrin derivatives. The company has strong technical force and close cooperation with Shandong University, Chinese Academy of Sciences and other first-class universities and scientific research institutes at home and abroad. It is a professional R & D and production enterprise with the largest variety and the most complete specifications in the cyclodextrin industry in China. Hydroxypropyl beta cyclodextrin and sulfobutyl ether beta cyclodextrin sodium salt are our two main products with complete qualification, and they have been registered on CDE, welcome to discuss. |
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Pharma Sources Insight June 2024: Globalization on the Go
