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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Sulfobutyl Ether-beta-Cyclodextrin Sodium CAS NO 182410-00-0
Grade Standard:injection grade
Usage: Pharmaceuticals field
Brand Name:Zhiyuan
Purity:99% Min
Appearance:White powder
Grade:USP
Certificate:ISO9001
Shelf life:2 Years
Main usage:
Sulfobutyl ether beta cyclodextrin sodium is a new type of anionic high soluble cyclodextrin derivatives. It could include drug molecules to from covalent compounds so that increase the drug’s stability,solubility,safety.It could reduce the renal toxicity,moderate drug’s hemolysis,control the release rate and cover up the bad smell.
It can be used as a solubilizer, wetting agent,chelating agent (complexing agent) and polyvalent masking agent.
It has been used in injection,oral,nasal and eye medicines.It could has a special affinity and inclusion |
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Betadex Sulfobutyl Ether Sodium;
Sulfobutyl Ether Beta Cyclodextrin Sodium,
Sodium sulfobutylether β-cyclodextrin;
Betadex Sulfobutyl Ether Sodium;
sulfobutyl ether B-cyclodextrin;sodiuM salts;
Betadex Sulfobutyl Ether Sodium property
Solubility Soluble in water. Insoluble in acetone, methanol, chloroform.
Form Solid powder
Color White to off white
Quick Details
· ProName:Betadex Sulfobutyl Ether Sodium 99%
· Cas No:182410-00-0
· Appearance:White powder
· Application:Functional Materials
· Delivery Time: immediately
· Pack Age:In aluminium foil bag or 10KG per drum
· Port: Beijing, Tianjin, Shanghai,Shenzhen
· Production Capacity: 6 tons/Month
· Purity:99%
· Storage:Room temperature
· Transportation:By Sea/Air
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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DMF No.: 030167
Name: Betadex sulfobutyl ether sodium
Other name: Sulfobutyl Ether-Beta-Cyclodextrin Sodium Salt;Sulfobutyl ether-β-cyclodextrin sodium salt;
CAS: 182410-00-0
Abbreviation: SBEBCD
Molecular formula: C42H70-nO35 (C4H8O3S Na)n
Molecular weight: 1135+158n
Solubility (in 100cm3 solvent, at 25℃) : Water:>50g ; Methanol:<0.5g ; Acetone:<0.5g
Qaulity: Injection grade
Standard: USP43
Package: 500g/bag , 1kg/bag , 2kg/bag, 10kg/drum or customized
Use : Medical
Specification:
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Standard
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USP43-NF38
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ITEMS
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CRITERIA
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Appearance
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White to off-white,amorphous powder.
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Solubility
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Freely soluble in water,sparingly soluble in methanol,practically insoluble in ethanol, in n-hexane, in 1-butanol, in acetonitrile,in 2-propanol and in ethyl acetate.
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Identification
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IR
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Same absorption bands as USP betadex sulfobutyl ether sodium RS.
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HPLC
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The retention time of the major peak of sample solution corresponds to the standard solution.
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Average Degree of Substitution
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Conform
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Sodium
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Identify test are positive for Sodium
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Assay
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95.0%~105.0%
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Beta Cyclodextrin
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≤0.1%
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1,4-Butane Sultone
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≤0.5ppm
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Sodium Chloride
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≤0.2%
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4-Hydroxybutane-1-sulfonic Acid
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≤0.09%
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Bis(4-sulfobtyl) Ether Disodium
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≤0.05%
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Bacterial Endotoxins
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≤20EU/g
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The total aerobic microbial count
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≤100cfu/g
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The total combined moulds and yeasts count
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≤50cfu/g
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Escherichia coli
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Absence
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Clarity of Solution
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30%(w/v) solution is clear and essentially free from particles of foreign matter.
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Average Degree of Substitution
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6.2~6.9
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Peaks I-X
(%peak area)
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I
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0.0~0.3
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II
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0.0~0.9
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III
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0.5~5.0
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IV
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2.0~10.0
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V
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10.0~20.0
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VI
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15.0~25.0
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VII
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20.0~30.0
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VIII
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10.0~25.0
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IX
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2.0~12.0
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X
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0.0~4.0
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pH
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4.0~6.8
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Water content
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≤10.0%
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Packaging and storage
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Preserve in well-closed containers,and store at room temperature. Protect from moisture.
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Features and applications:
SBE-β-CD is a high water-soluble anionic cyclodextrin derivative. It can easily form non-covalent inclusion complexes with drug molecules, thus it has the good performances in enhancing drug stability, solubility and safety, reducing drug toxicity and hemolysis, covering up bad smell, and controlling drug release rate.
SBE-β-CD has been used in injection, oral, nasal and eye medication. Modification by charged functional units can improve the binding affinity of cyclodextrins for oppositely charged guests, so it has a special affinity for drugs with nitrogen elements.
If you're looking for the high-quality sulfobutyl ether-beta-cyclodextrin sodium salt, our company must be your best choice. We're one of the leading manufacturers and supplier with rich experience and wide expertise. Please be rest assured to buy the products from our factory. |
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