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Fuan Pharmaceutical ( Group) Co., Ltd.
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Capecitabine is mainly used for advanced breast cancer, colorectal cancer, can be used as a rescue treatment for breast cancer after failure of anthracyclines and taxanes.
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Beijing ZhongShuo Pharmaceutical Technology Development Co.,Ltd.
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0.99 |
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Sinoway Industrial Co.Ltd.
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Product name
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Capecitabine
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Molecular Formula
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C15H22FN3O6
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Molecular Weight
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359.35
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CAS No.
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154361-50-9
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Quality Standard
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USP34, medical grade
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Appearance
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White powder
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Items
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Specifications
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Results
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Apperance
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White or off-white crystalline powder
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White crystalline powder
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Identification
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The spectrum of the sample corresponds to that of RS
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Meets the requirements
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The retention time of the major peak of the test solution corresponds to that of the RS
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Meets the requirements
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Specific Rotation
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+96.0°~+100.0°
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+98.1°
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Water
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≤0.3%
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0.01%
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Heavy Metals
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≤20ppm
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<20ppm
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(as Pb)
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Residue on ignition
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≤0.1%
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0.02%
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Assay
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98.0%~102.0%
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99.70%
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Function of Capecitabine
Capecitabine is rapidly absorbed through the intestinal mucosa after oral administration, and then converted into an inactive intermediate 5'-deoxy-5'fluorocytidine in the liver by carboxylesterase, and then decellularized by the liver and tumor The action of ammonia enzyme is converted into 5'-deoxy-5 'fluorouridine, and finally catalyzed by thymidine phosphorylase into fluorouracil (5-FU) in tumor tissue.
Clinical studies have shown that the concentration of 5-FU in tumor tissue after oral administration of this product is significantly higher than blood and muscle levels. The curative effect on various animal tumors is significantly higher than that of 5-FU. This product has a synergistic effect with a variety of anti-tumor drugs. |
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Pharma Sources Insight January 2025
