|
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
|
Hydroxypropyl Betadex FDA Manufacturers, Suppliers, Factory and Company - Zhiyuan Biological
Name: Hydroxypropyl betadex
CAS: 128446-35-5
Molecular formula :C42H70-nO35(C3H8O2)n
Molecular weight: 1134.98+58n
Qaulity : Pharma grade / food grade / cosmetics grade / industry grade
Standard : USP39/ EP9.0
Package: 500g/bag , 1kg/bag, 10kg/drum , 20kg/drum or customized
We have DMF certification。
1. In pharmaceuticals industry, hydroxypropyl-beta-cyclodextrin can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. hydroxypropyl-beta-cyclodextrin can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc.), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.
If you're looking for the high-quality hydroxypropyl betadex fda, our company must be your best choice. We're one of the leading manufacturers and supplier with rich experience and wide expertise. Please be rest assured to buy the products from our factory.
|
ITEMS
|
SPECIFICATION(USP39)
|
RESULTS
|
|
Appearance
|
white powder, insipid, innocent
|
Qualify
|
|
Assay
|
≥98％
|
99.5%
|
|
Degree of Substitution
|
2.8-10.5
|
5.5
|
|
Clarity of solution
|
50%(w/v) water solution is clear
|
clear
|
|
Identification(IR)
|
same absorption bands with USP Hydroxypropyl Betadex RS
|
Qualify
|
|
Loss on Drying
|
≤10％
|
4.5%
|
|
Conductivity
|
10%(w/v) water solution ≤200µS/cm
|
70
|
|
Propylene oxide
|
≤1ppm
|
＜0.18ppm
|
|
Propylene glycol
|
≤2.5％
|
0.05%
|
|
Sum of Other Impurities
|
≤1％
|
0.51%
|
|
Betadex
|
≤1.5%
|
0.39%
|
|
Residue on Ignition
|
≤0.2％
|
0.09%
|
|
Heavy Metal
|
≤20ppm
|
＜10ppm
|
|
chloride
|
≤0.05%
|
＜0.05%
|
|
Bacterial endotoxins
|
≤20EU/g
|
<20EU/g
|
|
TAMC(cfu/g)
|
≤1000
|
＜10
|
|
TYMC(cfu/g)
|
≤100
|
＜10
|
Hot Tags: hydroxypropyl betadex fda, manufacturers, suppliers, factory, company, buy, high-quality
|
Send Inquiry
|
|
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
|
Description:
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a water-soluble cyclic heptasaccharide used to deliver hydrophobic drugs based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent.
In Vitro:
Methyl-β-cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles.
Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs.
Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner.
Methyl-β-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents.
In Vivo:
In a PEL xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice.
Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. |
Send Inquiry
|
|
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
|
Methyl-β-cyclodextrin is a water-soluble cyclic heptasaccharide used to deliver hydrophobic drugs based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent.
In Vitro:
Methyl cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles.
Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs.
Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner.
Methyl-β-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents.
In Vivo:
In a PEL xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice.
Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. |
Send Inquiry
|
Pharma Sources Insight June 2024: Globalization on the Go
