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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Hydroxypropyl Beta cyclodextrin (HP – beta- CD) is beta Cyclodextrin a kind of hydroxyl alkylation derivatives.Widely used in Pharmaceutical Drug for human,Food,Cosmetic and Chemical.
Use in Medical Field
1.An ideal injection solubilizer and drug excipients because of lower surface activity and hemolytic activity, no muscle irritation.
2.Hydroxypropyl Beta Cyclodextrin can increase the solubility of the medicine and biological availability, also increase durg's curative effect thus decrease the dose.
3.Meanwhile,Hydroxypropyl Beta Cyclodextrin can control drug release rate, lower drug toxicity and enhance stability. |
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Hydroxypropyl beta cyclodextrin can be used as a stabilizer, emulsifier,to taste agent,etc.
Hydroxypropyl beta cyclodextrin keep the fragrance slow release and lasting.
Hydroxypropyl beta cyclodextrin can increase the difficult soluble essence,
water soluble spices.
Shandong Binzhou Zhiyuan technology Co., Ltd. is a researching and manufacturing company specialized in pharmaceutical and chemical products.We are leading manufacturer of Hydroxypropyl betadex for 10 years in Binzhou City, Shandong province,China.
Guided by honest principles and committed to international standard, we sincerely hope to cooperate. |
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
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Description
(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.
In Vitro
Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin.
In Vivo
(2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects.
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Pharma Sources Insight January 2025
