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Sinoway Industrial Co.Ltd.
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Product name
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Ademetionine 1,4-butanedisulfonate / SAM / SAMe
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CAS No.
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101020-79-5
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Molecular Formula
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C23H41N6O17S5-
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Molecular Weight
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833.91
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Quality Standard
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99% up by HPLC
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Appearance
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White powder
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COA of Ademetionine 1,4-butanedisulfonate
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ITEMS
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STANDARDS
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RESULTS
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Appearance
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A white or almost white powder
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White powder
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Solubility
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Freely soluble in water, practically insoluble in ethanol and in acetone.
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Conforms
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Identification
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1. The gas it produced can make wet potassium iodate test pater show blue.
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Conforms
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2. UV: it has absorption maximum at the 258nm
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3. HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference.
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pH
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2.1~2.5
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2.4
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Clarity and color of solution
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Color: ≤Y3# or YG3#
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Conforms
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A solution should be clear.
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Isomers
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(S,S-Isomer) ≥70%
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74.00%
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Related substances
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Adenine≤0.4%
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0.05%
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S-Adenosyl-L-Homocysteine≤0.4%
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0.09%
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Methylthioadenosine≤2.0%
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0.43%
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Decarboxylation adenosine methionine≤1.2%
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1.00%
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The other unknown impurities≤1.0%
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0.05%
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Total of impurities≤4.0%
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1.80%
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Water
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≤6.0%
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2.40%
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Residual solvents
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Ethyl acetate≤5000ppm
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Conforms
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Microbial limit tests
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Bacteria≤1000cfu/g
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Conforms
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Bacterial endotoxins
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≤0.438 EU/mg
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Conforms
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Content (dried basis)
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Butanedisuphonic acid: 46.0~51.0%
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47.20%
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Adenosine methionine: 48.0~53.0%
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52.20%
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Total≥96.0%
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99.40%
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Conclusion
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Conforms to enterprise standard
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Function of Ademetionine 1,4-butanedisulfonate
Ademetionine 1,4-butanedisulfonate (SAM / SAMe) is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, coenzyme A, etc.) (transsulfation) , participates important functions of biochemical reaction in the body.
The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:
1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.
2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.
3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.
Indication of Ademetionine 1,4-butanedisulfonate:
Suitable for intrahepatic cholestasis before and after cirrhosis.
Suitable for intrahepatic cholestasis during pregnancy. |
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